![]() ![]() GLOBOCAN 2018 reported region-specific incidence and age-standardized mortality rate for BC in Western Asia (incidence: 45.3/100,000, mortality: 13.6/100,000) and Eastern Asia (incidence: 39.2/100,000, mortality: 8.6/100,000) ( 1). Among females, BC is the most frequently diagnosed and the leading cause of cancer mortality. Our data suggest future development of therapeutic interventions targeting those common signaling pathways.īreast cancer (BC) is the second most common type of cancer around the world comprising approximately 11.6% of new cancer cases and 6.6% of all cancer-related deaths up to 2018 ( 1). Our data provide novel insight on BC biology and suggest common altered molecular networks in BC in this geographic region. We observed high concordance between differentially expressed genes in our study group and those reported for the TCGA BC cohort. The presence of genes indicative of immune cell infiltration and activation was also observed in BC tissue. Additionally, BC tissue exhibited marked enrichment in genes promoting cellular proliferation, migration, survival, and DNA replication and repair. Activation of ERBB2, FOXM1, ESR1, and IGFBP2 mechanistic networks was most prominent in BC tissue. p < 0.05) transcripts were subjected to ingenuity pathway analysis, which revealed a myriad of affected signaling pathways and functional categories. Differentially expressed (2.0-fold change, adj. A selected number of genes from the RNA-Seq analysis were subsequently validated using qRT-PCR. Herein, we compared the transcriptome of BC to adjacent normal tissue from six BC patients and identified 1,108 upregulated and 518 downregulated transcripts. This study aimed to provide a better understanding of the altered molecular networks in BC from the gulf region. Although a number of transcriptomic studies have been performed on breast cancer patients from various geographic regions, there are almost no such comprehensive studies performed on breast cancer from patients in the gulf region. Therefore, a better understanding of BC biology and signaling pathways might lead to the development of novel biomarkers and targeted therapies. Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatarīreast cancer (BC) is the leading cause of cancer-related death in women.Radhakrishnan Vishnubalaji †, Varun Sasidharan Nair †, Khalid Ouararhni, Eyad Elkord * and Nehad M. ![]()
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